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John Gill
Then came to him his mother and his brethren,.... It was when Christ was preaching in an house at Capernaum, that Mary his mother, and some of his near kinsmen with her, came from Nazareth to him: these brethren of his were relations according to the flesh, either by Joseph, or his mother's side: who they were, cannot be said with certainty: it may be they were Joses and Simon; for as for James...
Matthew Henry
Most of this chapter is a repetition of divers passages of Christ's preaching and miracles which we had before in Matthew and Mark; they are all of such weight, that they are worth repeating, and therefore they are repeated, that out of the mouth not only of two, but of three, witnesses every word may be established. Here is, I. A general account of Christ's preaching, and how he had subsistence...
Charles H. Spurgeon
Then came to him his mother and his brethren, and could not come at him for the press. I think that his mother and his brethren were under the delusion that he was mad, and they came to seize him, to restrain him, so little did even they understand him.